Comparison of Risk Factor between Lacunar Stroke and Large Artery Atherosclerosis Stroke: A Cross-Sectional Study in China

PLoS One. 2016 Mar 2;11(3):e0149605. doi: 10.1371/journal.pone.0149605. eCollection 2016.


Background: Stroke is the second most common cause of mortality in China. Although most subtypes of ischemic stroke share similar risk factors, they have different etiologies. Our study aimed to evaluate the different risk factor profiles between the stroke subtypes, lacunar infarcts (LI) and large-artery atherosclerosis (LAA), and clarify the characteristics of current acute ischemic stroke in China.

Methods: In this cross-sectional study, we analyzed the clinical characteristics of 1982 patients with acute ischemic stroke who were admitted to the neurology department at the Peking University First Hospital between 2007 and 2014. Ischemic stroke was further classified into LAA, LI, cardioembolism (CE) and undetermined causes of infarction (UDI) according to TOAST classification. Demographic characteristics, risk factors, as well as the findings of laboratory and imaging tests of 1773 patients with LAA and LI, were analyzed by univariate and multivariate logistic analysis.

Results: Of the 1982 ischemic stroke patients included in this study, 1207 were diagnosed with LAA, 566 with LI, 173 with cardioembolism (CE) and 36 with undetermined causes of infarction (UDI). By comparing the risk factors in multivariate logistic regression analysis, hypertension [odds ratio (OR) = 1.832] and white matter leukoaraiosis (WML) (OR = 1.865) were found to be more strongly correlated with LI than LAA. Low density lipoprotein- cholesterol (LDL-c) (OR = 0.774) were more strongly related to LAA than LI.

Conclusions: This study found that hypertension and WML were more strongly correlated with LI than LAA. LDL-c was more strongly related to LAA than LI.

Publication types

  • Comparative Study

MeSH terms

  • Aged
  • Arteries / metabolism
  • Arteries / pathology*
  • Atherosclerosis / complications*
  • Atherosclerosis / metabolism
  • Brain Ischemia / complications
  • Brain Ischemia / metabolism
  • China
  • Cholesterol, LDL / metabolism
  • Cross-Sectional Studies
  • Female
  • Humans
  • Male
  • Middle Aged
  • Risk Factors
  • Stroke, Lacunar / etiology*
  • Stroke, Lacunar / metabolism


  • Cholesterol, LDL

Associated data

  • figshare/10.6084/M9.FIGSHARE.1561426

Grant support

The authors received no specific funding for this work.