Bioactive Secondary Metabolites with Unique Aromatic and Heterocyclic Structures Obtained from Terrestrial Actinomycetes Species

Chem Pharm Bull (Tokyo). 2016 Jul 1;64(7):668-75. doi: 10.1248/cpb.c16-00038. Epub 2016 Mar 2.

Abstract

Natural products from actinomycetes are important and valuable sources for drug discovery and the development of biological tools. The present review describes our recent study on the isolation of new natural products mainly possessing heterocyclic and aromatic ring structures with biological effects on cancer-related cellular pathways such as tumor necrosis factor-α-related apoptosis-inducing ligand (TRAIL) and Wnt signaling.

Publication types

  • Review

MeSH terms

  • Actinobacteria / chemistry*
  • Biological Products / chemistry
  • Biological Products / isolation & purification*
  • Biological Products / metabolism
  • Biological Products / pharmacology*
  • Heterocyclic Compounds / chemistry*
  • Heterocyclic Compounds / isolation & purification
  • Heterocyclic Compounds / metabolism
  • Heterocyclic Compounds / pharmacology*
  • Humans
  • Hydrocarbons, Aromatic / chemistry*
  • Hydrocarbons, Aromatic / isolation & purification
  • Hydrocarbons, Aromatic / metabolism
  • Hydrocarbons, Aromatic / pharmacology*
  • Secondary Metabolism*
  • TNF-Related Apoptosis-Inducing Ligand / antagonists & inhibitors
  • TNF-Related Apoptosis-Inducing Ligand / metabolism
  • Wnt Signaling Pathway / drug effects

Substances

  • Biological Products
  • Heterocyclic Compounds
  • Hydrocarbons, Aromatic
  • TNF-Related Apoptosis-Inducing Ligand
  • TNFSF10 protein, human