Prospect and progress of personalized peptide vaccinations for advanced cancers

Expert Opin Biol Ther. 2016;16(5):689-98. doi: 10.1517/14712598.2016.1161752. Epub 2016 Mar 21.


Introduction: The field of cancer immunotherapy has made dramatic progress in the past 20 years, in part due to the identification of numerous tumor-associated antigens (TAAs). We have developed a novel immunotherapeutic approach called the personalized peptide vaccine (PPV), in which a maximum of four human leukocyte antigen (HLA)-matched vaccine peptides are selected based on the pre-existing host immunity before vaccination.

Areas covered: This review describes recent progress in the use of PPV for various types of advanced cancer.

Expert opinion: Although various approaches for therapeutic cancer immunotherapies, including peptide-based vaccines, have been developed and clinically examined, the diverse and heterogeneous characteristics of tumor cells and host immunity seem to limit their therapeutic efficacy. Selection of suitable peptide vaccines for individual patients based on the pre-existing host immunity before vaccination could resolve this limitation and could be a rational approach for developing effective cancer vaccines.

Keywords: Advanced cancer; biomarker; cancer immunotherapy; cancer vaccine; clinical trial; peptide epitope; personalized peptide vaccine.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antigens, Neoplasm / immunology
  • Cancer Vaccines / therapeutic use*
  • Humans
  • Immunotherapy / methods*
  • Neoplasms / therapy*
  • Peptides / therapeutic use
  • Precision Medicine / methods
  • Vaccination
  • Vaccines, Subunit / therapeutic use


  • Antigens, Neoplasm
  • Cancer Vaccines
  • Peptides
  • Vaccines, Subunit