Electroacupuncture for Tinnitus: A Systematic Review

PLoS One. 2016 Mar 3;11(3):e0150600. doi: 10.1371/journal.pone.0150600. eCollection 2016.

Abstract

Background: Treatment effects of electroacupuncture for patients with subjective tinnitus has yet to be clarified.

Objectives: To assess the effect of electroacupuncutre for alleviating the symptoms of subjective tinnitus.

Methods: Extensive literature searches were carried out in three English and four Chinese databases (PubMed, EMBASE, Cochrane Library, CNKI, Wanfang Chinese Digital Periodical and Conference Database, VIP, and ChiCTR).The date of the most recent search was 1 June 2014. Randomized controlled trials (RCTs) or quasi-RCTs were included. The titles, abstracts, and keywords of all records were reviewed by two authors independently. The data were collected and extracted by three authors. The risk of bias in the trials was assessed in accordance with the Cochrane Handbook, version 5.1.0. (http://www.handbook.cochrane.org). Eighty-nine studies were retrieved. After discarding 84 articles, five studies with 322 participants were identified. Assessment of the methodological quality of the studies identified weaknesses in all five studies. All studies were judged as having a high risk of selection and performance bias. The attrition bias was high in four studies. Incompleteness bias was low in all studies. Reporting bias was unclear in all studies. Because of the limited number of trials included and the various types of interventions and outcomes, we were unable to conduct pooled analyses.

Conclusions: Due to the poor methodological quality of the primary studies and the small sample sizes, no convincing evidence that electroacupuncture is beneficial for treating tinnitus could be found. There is an urgent need for more high-quality trials with large sample sizes for the investigation of electroacupuncture treatment for tinnitus.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review
  • Systematic Review

MeSH terms

  • Acupuncture Therapy*
  • Electroacupuncture*
  • Humans
  • Publication Bias*
  • Randomized Controlled Trials as Topic
  • Tinnitus / physiopathology
  • Tinnitus / therapy

Grants and funding

This study is partially funded by the National Natural Science Foundation of China (No.81273985 & No. 81473523), National Science & Technology Pillar Program during the Twelfth Five-year Plan Period of China (No. 2015BAI04B00). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.