Inside Out: Core Network of Transcription Factors Drives Axon Regeneration

Neuron. 2016 Mar 2;89(5):881-4. doi: 10.1016/j.neuron.2016.02.022.


In this issue, Chandran et al. (2016) pursue a multi-level bioinformatics approach combined with wet bench validation to identify gene networks associated with the regenerative state of injured adult sensory neurons. A small molecular compound, ambroxol, mimics aspects of the identified gene expression patterns and promotes axon regeneration in the injured adult mouse CNS, demonstrating feasibility of in silico-based methods to identify compounds that promote neuronal growth following CNS injury.

Publication types

  • Comment

MeSH terms

  • Animals
  • Axons / physiology*
  • Ganglia, Spinal / cytology*
  • Nerve Regeneration / physiology*
  • Neurons / cytology*
  • Peripheral Nervous System Diseases / physiopathology*