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. 2016 Apr 11;22(16):5534-7.
doi: 10.1002/chem.201600154. Epub 2016 Mar 3.

1,2,3-Triazole Bridge as Conformational Constrain in β-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions

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1,2,3-Triazole Bridge as Conformational Constrain in β-Hairpin Peptides: Analysis of Hydrogen-Bonded Positions

V Celentano et al. Chemistry. .
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Abstract

Conformational constrained β-hairpin peptides are useful tool to modulate protein-protein interactions. A triazole bridge in hydrogen-bonded positions between two antiparallel strands induces a conformational stabilization of the β-hairpin peptide. The entity of the stability of the β-hairpin peptide depends on the length of the bridge.

Keywords: NMR spectroscopy; click chemistry; cycloaddition; peptidomimetics; β-hairpin.

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