The Yersinia Yop Regulon

Mol Microbiol. 1989 Oct;3(10):1455-9. doi: 10.1111/j.1365-2958.1989.tb00129.x.


Growth of yersiniae is restricted at 37 degrees C in the absence of calcium ions. This phenomenon correlates with the massive release of a set of proteins called Yops. Growth restriction and Yops production are governed by a 70 kb plasmid called pYV. yop genes are distributed throughout pYV and constitute a thermoactivated regulon controlled by the gene virF. The transcription activator VirF is a member of a new family of regulators including those of the arabinose and rhamnose operons as well as a regulator of enteric colonization pili. The role of calcium ions on the release of Yops remains largely unknown.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Bacterial Adhesion
  • Bacterial Outer Membrane Proteins / analysis
  • Bacterial Proteins / biosynthesis
  • Bacterial Proteins / genetics*
  • Calcium / physiology
  • Gene Expression Regulation, Bacterial
  • Genes, Regulator* / physiology
  • Yersinia / genetics*
  • Yersinia / pathogenicity


  • Bacterial Outer Membrane Proteins
  • Bacterial Proteins
  • Yop5 (Yersinia)
  • Calcium