Beneficial Effect of Covalently Grafted α-MSH on Endothelial Release of Inflammatory Mediators for Applications in Implantable Devices

PLoS One. 2016 Mar 3;11(3):e0150706. doi: 10.1371/journal.pone.0150706. eCollection 2016.


Intravascular devices for continuous glucose monitoring are promising tools for the follow up and treatment of diabetic patients. Limiting the inflammatory response to the implanted devices in order to achieve better biocompatibility is a critical challenge. Herein we report on the production and the characterization of gold surfaces covalently derivatized with the peptide α-alpha-melanocyte stimulating hormone (α-MSH), with a quantifiable surface density. In vitro study demonstrated that the tethered α-MSH is able to decrease the expression of an inflammatory cytokine produced by endothelial cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry*
  • Blood Glucose Self-Monitoring / instrumentation*
  • Blood Glucose Self-Monitoring / methods
  • Cell Adhesion
  • Electrochemistry
  • Endothelial Cells / cytology
  • Glucose / chemistry
  • Gold / chemistry
  • Human Umbilical Vein Endothelial Cells
  • Humans
  • Hydrolysis
  • Inflammation
  • Interleukin-6 / chemistry
  • Lipopolysaccharides / chemistry
  • Maleimides / chemistry
  • Microscopy, Fluorescence
  • Peptides / chemistry
  • Prostheses and Implants
  • Spectrometry, X-Ray Emission
  • Sulfhydryl Compounds / chemistry
  • Surface Properties
  • alpha-MSH / metabolism*


  • Biocompatible Materials
  • Interleukin-6
  • Lipopolysaccharides
  • Maleimides
  • Peptides
  • Sulfhydryl Compounds
  • maleimide
  • alpha-MSH
  • Gold
  • Glucose

Grant support

This work has benefited from a French State grant (reference ANR-10-LABX-0042- AMADEus) managed by the French National Research Agency under the initiative of excellence IdEx Bordeaux program (reference n°ANR-10-IDEX-0003-02).