Abstract
The liver performs a vital role in metabolism, secretion, storage, and detoxification of endogenous and exogenous substances. Oxidative stress and free radicals enhance the severity of hepatic damage, which can be overcome by the antioxidant mechanism. Plant extracts can be the best source of such antioxidants and mediate hepatoprotective activity. In this chapter, high-dose paracetamol-induced hepatotoxicity in rat model is discussed with explanations of biochemical and histopathological studies.
MeSH terms
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Acetaminophen
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Animals
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Antioxidants / isolation & purification
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Antioxidants / pharmacology*
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Bioprospecting / methods*
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Chemical and Drug Induced Liver Injury / metabolism
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Chemical and Drug Induced Liver Injury / pathology
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Chemical and Drug Induced Liver Injury / prevention & control*
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Cytoprotection
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Disease Models, Animal
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Drug Discovery / methods*
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Female
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Liver / drug effects
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Liver / metabolism
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Liver / pathology
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Male
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Oxidative Stress / drug effects
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Phytochemicals / isolation & purification
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Phytochemicals / pharmacology*
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Phytotherapy
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology*
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Plants, Medicinal
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Rats, Wistar
Substances
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Antioxidants
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Phytochemicals
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Plant Extracts
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Acetaminophen