B-cell Non-Hodgkin Lymphomas with Plasmacytic Differentiation

Surg Pathol Clin. 2016 Mar;9(1):11-28. doi: 10.1016/j.path.2015.09.007.


B-cell non-Hodgkin lymphomas with plasmacytic differentiation are a diverse group of entities with extremely variable morphologic features. Diagnostic challenges can arise in differentiating lymphoplasmacytic lymphoma from marginal zone lymphoma and other low-grade B-cell lymphomas. In addition, plasmablastic lymphomas can be difficult to distinguish from diffuse large B-cell lymphoma or other high-grade lymphomas. Judicious use of immunohistochemical studies and molecular testing can assist in appropriate classification.

Keywords: Lymphoma; Lymphoplasmacytic; MALT; Nodal marginal zone; Plasmablastic; Plasmacytic; Splenic.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Humans
  • Immunophenotyping
  • Lymphoma, B-Cell / diagnosis*
  • Lymphoma, B-Cell / immunology
  • Lymphoma, B-Cell / pathology
  • Lymphoma, B-Cell, Marginal Zone / diagnosis
  • Lymphoma, B-Cell, Marginal Zone / immunology
  • Lymphoma, B-Cell, Marginal Zone / pathology
  • Plasmacytoma / diagnosis
  • Plasmacytoma / immunology
  • Plasmacytoma / pathology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / diagnosis
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / immunology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / pathology
  • Prognosis
  • Waldenstrom Macroglobulinemia / diagnosis*
  • Waldenstrom Macroglobulinemia / immunology
  • Waldenstrom Macroglobulinemia / pathology

Supplementary concepts

  • Plasmacytoma anaplastic