Radioresistance induced by oncogenic transformation

Radiat Res. 1989 Nov;120(2):267-79.

Abstract

Rat embryo cells at various stages of oncogenic transformation are obtained by a combination of X irradiation and transfection with the ras and the myc oncogenes. Transfection with either the ras or the myc oncogenes can lead to increased radioresistance, relative to the parental cells. X-ray-transformed clones of the transfected cells do not show additional alteration in radioresponse. Incorporation of the two oncogenes appears to lead to a higher degree of radioresistance.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cell Survival / radiation effects
  • Cell Transformation, Neoplastic* / radiation effects
  • Dose-Response Relationship, Radiation
  • Genes, ras
  • In Vitro Techniques
  • Oncogenes*
  • Radiation Tolerance / genetics*
  • Rats
  • Transfection*