Bone Quality in Paget's Disease of Bone

Curr Osteoporos Rep. 2016 Apr;14(2):39-42. doi: 10.1007/s11914-016-0303-6.


Paget's disease of bone is produced by a localized increase in osteoclastic and osteoblastic activity which can progress slowly to involve an entire bone if untreated. A common feature is enlarged bones which are deformed, particularly in weight-bearing regions of the skeleton such as the lower extremity. Pathologic fractures may be a consequence, and nonunion of femoral fractures is not uncommon. Analyses of bone biopsies from patients with Paget's disease indicate that there is a lower, heterogeneous degree of bone mineralization and a younger tissue age than that found in control bone. Pagetic bone also has less resistance to plastic deformation and a straighter crack path than control bone.

Publication types

  • Review

MeSH terms

  • Absorptiometry, Photon
  • Aged
  • Aged, 80 and over
  • Biomechanical Phenomena
  • Bone and Bones / abnormalities*
  • Bone and Bones / chemistry
  • Bone and Bones / pathology*
  • Bone and Bones / physiopathology
  • Calcification, Physiologic
  • Collagen / analysis
  • Female
  • Fractures, Bone / epidemiology
  • Humans
  • Osteitis Deformans / diagnostic imaging
  • Osteitis Deformans / pathology*
  • Osteitis Deformans / physiopathology


  • Collagen