[Hematopoietic progenitors transplantation in a patient with chronic granulomatous disease in Mexico]

Rev Alerg Mex. Jan-Mar 2016;63(1):95-103. doi: 10.29262/ram.v63i1.134.
[Article in Spanish]

Abstract

The incidence of chronic granulomatous disease in international reports is 1:250,000; however, in Mexico it is unknown. At the National Institute of Pediatrics of Mexico a project for facilitating the diagnosis of the disease was implemented by us in 2009. From the start of such project up to date 68 cases have been studied; 80% of those are X-linked forms (LX) and moreover, it has become noticeable the diagnosis at a younger age. The new challenge we are facing its to provide a successful treatment to those patients diagnosed with chronic granulomatous disease (CGD). We are reporting the case of a one-month old newborn patient diagnosed with CGD-LX that was successfully transplanted in Mexico.

La incidencia de la enfermedad granulomatosa crónica en reportes internacionales es de 1:250,000; sin embargo, en México se desconoce. En el Instituto Nacional de Pediatría, a partir de 2009 se implementó un proyecto para facilitar el diagnóstico de esa enfermedad. De esa fecha al día de hoy se han estudiado 68 casos, de los que 80% son formas ligadas al cromosoma X, además de que cada vez los casos se han diagnosticado a una edad más temprana. En la actualidad nos encontramos con un nuevo reto: el tratamiento curativo de los pacientes con enfermedad granulomatosa crónica. Comunicamos el caso de un paciente con enfermedad granulomatosa crónica ligada al cromosoma X, trasplantado exitosamente al mes de vida en México.

Keywords: chronic granulomatous disease; hematopoietic progenitors; transplant.

Publication types

  • Case Reports

MeSH terms

  • Granulomatous Disease, Chronic / genetics
  • Granulomatous Disease, Chronic / therapy*
  • Hematopoietic Stem Cell Transplantation*
  • Humans
  • Infant, Newborn
  • Mexico
  • Syndrome