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. 2016;21:70-2.
doi: 10.1016/j.ijscr.2016.02.031. Epub 2016 Mar 2.

Pancreatic Manifestations in Von Hippel-Lindau Disease: A Case Report

Free PMC article

Pancreatic Manifestations in Von Hippel-Lindau Disease: A Case Report

Subhashini Ayloo et al. Int J Surg Case Rep. .
Free PMC article


Introduction: Pancreatic manifestations in Von Hippel-Lindau (VHL) disease can present as a multitude of forms, and their management can be challenging.

Presentation of the case: A 66-year-old woman presented with increasing abdominal girth without other associated symptoms of nausea, vomiting, abdominal pain, weight-loss, and jaundice. Her medical and surgical histories were significant for type II diabetes, cerebral tumor resection, bilateral nephrectomies, and laser photocoagulation of retinal hemangiomas. Computed tomography (CT) of the abdomen showed a massive multi-cystic lesion in the pancreas and the patient was referred to our hepatopancreatic biliary center.

Discussion: The findings on the subsequent cross-sectional MRI imaging signified pancreatic manifestations in VHL disease.

Conclusion: The management of VHL disease-associated benign pancreatic cystic lesions involves interval monitoring with cross-sectional imaging for malignant changes/development.

Keywords: Case report; Pancreatic cyst; Pancreatic neuroendocrine tumor; Serous cystadenoma; Von Hippel–Lindau disease.


Fig. 1
Fig. 1
Magnetic resonance imaging of abdomen (panel A–D). Arrow head: multiple pancreatic cysts; single arrow: benign simple cysts; oval arrow: serous cystadenomas.

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