Neonatal adiposity increases with rising cord blood IGF-1 levels

Clin Endocrinol (Oxf). 2016 Jul;85(1):70-5. doi: 10.1111/cen.13057. Epub 2016 Mar 31.


Objective: Infants with higher adiposity at birth may be at greater risk of developing obesity later in life. IGF-1 is important for intrauterine growth and may be a useful early life marker of adiposity, and thus later obesity risk. The aim of this study was to determine the relationship between cord blood IGF-1, neonatal anthropometrics and markers of neonatal adiposity.

Design, patients and measurements: A cross-sectional study design was utilized to study a multiethnic cohort of full-term neonates born to healthy mothers with normal glucose tolerance at a large university hospital. Neonatal cord blood was collected after birth and assayed for IGF-1, leptin and C-peptide. Neonatal body composition was measured between 24 and 72 h of life using the method of air displacement plethysmography.

Results: Cord blood IGF-1 was positively and significantly associated with markers of neonatal adiposity in models adjusted for maternal age at delivery, race, maternal prepregnancy BMI, gestational age at delivery and neonatal sex: birthweight (r = 0·62, P < 0·001), leptin (r = 0·33, P = 0·018), fat mass (r = 0·52, P < 0·001) and percent body fat (r = 0·51, P < 0·001). Cord blood IGF-1 was not associated with cord blood C-peptide.

Conclusions: Cord blood IGF-1 is strongly associated with all measures of neonatal adiposity suggesting that IGF-1 may be an important contributor to in utero neonatal fat accumulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adiposity*
  • Adult
  • Body Composition
  • C-Peptide / blood
  • Cross-Sectional Studies
  • Female
  • Fetal Blood / chemistry*
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Insulin-Like Growth Factor I / analysis*
  • Insulin-Like Growth Factor I / physiology*
  • Leptin / blood
  • Male
  • Maternal Age
  • Pregnancy


  • C-Peptide
  • Leptin
  • Insulin-Like Growth Factor I

Associated data

  • GENBANK/HD055884