Characterization of a novel qepA3 variant in Enterobacter aerogenes

J Microbiol Immunol Infect. 2017 Apr;50(2):254-257. doi: 10.1016/j.jmii.2016.01.001. Epub 2016 Feb 10.


Five isolates harboring qepA were studied by polymerase chain reaction (PCR) amplification and relevant methods. One was determined to be a novel qepA3 from Enterobacter aerogenes, and four involved three qepA1 and one qepA2 determinants from Escherichia coli; the qepA3 changed five amino acids. These results characterized genetic structures A, B, C, D, and E.

Keywords: Enterobacter aerogenes; Escherichia coli; genetic structure; novel qepA3 variant gene; quinolone resistance.

MeSH terms

  • Anti-Infective Agents / pharmacology
  • Bacterial Proteins / genetics*
  • DNA, Bacterial / genetics
  • Drug Resistance, Bacterial
  • Enterobacter aerogenes / drug effects
  • Enterobacter aerogenes / genetics*
  • Enterobacter cloacae / drug effects
  • Enterobacter cloacae / genetics
  • Enterobacteriaceae Infections / microbiology
  • Escherichia coli / drug effects
  • Escherichia coli / genetics
  • Genes, Bacterial
  • Genetic Structures
  • Microbial Sensitivity Tests
  • Point Mutation
  • Polymerase Chain Reaction / methods
  • Quinolones / pharmacology


  • Anti-Infective Agents
  • Bacterial Proteins
  • DNA, Bacterial
  • Quinolones