Association of Prenatal Antibiotics With Foetal Size and Cord Blood Leptin and Adiponectin

Pediatr Obes. 2017 Apr;12(2):129-136. doi: 10.1111/ijpo.12119. Epub 2016 Mar 7.

Abstract

Background: Early postnatal antibiotic use has been shown to promote excess weight gain, but it is unclear whether intrauterine exposure to antibiotics is associated with foetal growth and adiposity. The objective of this study was to examine associations of antibiotic prescription in each trimester of pregnancy with foetal size and adipokine levels at birth.

Methods: In 2128 pregnant women from the pre-birth Project Viva cohort, from electronic medical records, we estimated antibiotic prescribing by timing during pregnancy. Outcomes were sex-specific birth weight-for-gestational-age z-score (BW/GA-z) and levels of umbilical cord leptin and adiponectin. We used linear regression models adjusted for maternal age, pre-pregnancy body mass index, parity, race/ethnicity, education, smoking during pregnancy, household income and child sex and additionally adjusted cord blood leptin and adiponectin models for gestation length.

Results: Of the 2128 women in our sample, 643 (30.2%) were prescribed with oral antibiotics during pregnancy. Mean (standard deviation) BW/GA-z was 0.17 (0.97), cord blood leptin was 9.0 ng mL-1 (6.6) and cord blood adiponectin was 28.8 ng mL-1 (6.8). Overall, antibiotic prescription in pregnancy was associated with lower BW/GA-z [multivariable adjusted β -0.11; 95% confidence interval {CI} -0.20, -0.01]. In trimester-specific analyses, only second trimester antibiotic prescription was associated with lower BW/GA-z (β -0.23; 95% CI -0.37, -0.08). Overall, antibiotic prescription in pregnancy was not associated with cord blood leptin or adiponectin levels. However, in trimester-specific analyses, third trimester antibiotic prescription was associated with higher cord blood leptin (β 2.28 ng mL-1 ; 95% CI 0.38, 4.17).

Conclusions: Antibiotics in mid-pregnancy were associated with lower birth weight for gestational age, whereas third trimester antibiotics were associated with higher cord blood leptin.

Keywords: Adiponectin; antibiotics; foetal growth; leptin.

MeSH terms

  • Adiponectin / blood*
  • Adult
  • Anti-Bacterial Agents / adverse effects*
  • Birth Weight
  • Body Mass Index
  • Female
  • Fetal Blood / metabolism*
  • Fetal Development / drug effects*
  • Gestational Age
  • Humans
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Leptin / blood*
  • Linear Models
  • Male
  • Pregnancy
  • Prenatal Exposure Delayed Effects

Substances

  • ADIPOQ protein, human
  • Adiponectin
  • Anti-Bacterial Agents
  • Leptin