Effects of fish oil capsules in two dosages on blood pressure, platelet functions, haemorheological and clinical chemistry parameters in apparently healthy subjects

Ann Nutr Metab. 1989;33(6):359-67. doi: 10.1159/000177559.


The effects of a fish oil concentrate with an omega-3 fatty acid content of 42% was determined in two dosages in a double-blind, placebo-controlled study with a parallel group comparison over a period of 5 weeks with 30 healthy subjects. The daily intake chosen was four and eight capsules corresponding to 1.26 or 2.52 g omega-3 fatty acids. Plasma viscosity, erythrocyte rigidity and systolic blood pressure were significantly decreased (p less than 0.01) after a 5-week administration of 2.52 g omega-3 fatty acid daily. The reduction in vitamin E concentration was significant (p less than 0.01) only in the low-dose fish oil group. Lipids and lipoproteins remained unchanged throughout this experiment.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Blood Platelets / physiology*
  • Blood Pressure*
  • Blood Viscosity
  • Capsules
  • Clinical Trials as Topic
  • Double-Blind Method
  • Erythrocyte Deformability
  • Female
  • Fish Oils / administration & dosage*
  • Humans
  • Lipids / blood*
  • Male
  • Platelet Aggregation


  • Capsules
  • Fish Oils
  • Lipids