Midbrain dopamine neurons compute inferred and cached value prediction errors in a common framework

Elife. 2016 Mar 7;5:e13665. doi: 10.7554/eLife.13665.

Abstract

Midbrain dopamine neurons have been proposed to signal reward prediction errors as defined in temporal difference (TD) learning algorithms. While these models have been extremely powerful in interpreting dopamine activity, they typically do not use value derived through inference in computing errors. This is important because much real world behavior - and thus many opportunities for error-driven learning - is based on such predictions. Here, we show that error-signaling rat dopamine neurons respond to the inferred, model-based value of cues that have not been paired with reward and do so in the same framework as they track the putative cached value of cues previously paired with reward. This suggests that dopamine neurons access a wider variety of information than contemplated by standard TD models and that, while their firing conforms to predictions of TD models in some cases, they may not be restricted to signaling errors from TD predictions.

Keywords: dopamine; neuroscience; prediction error; rat; single unit.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • Animals
  • Behavior, Animal*
  • Conditioning, Operant / physiology
  • Cues
  • Dopaminergic Neurons / physiology*
  • Female
  • Male
  • Mesencephalon / physiology*
  • Models, Neurological*
  • Rats, Long-Evans
  • Reward*