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. 2016 Mar 2;21(3):304.
doi: 10.3390/molecules21030304.

Anti-Oxidant, Anti-Inflammatory and Anti-Angiogenic Properties of Resveratrol in Ocular Diseases

Free PMC article

Anti-Oxidant, Anti-Inflammatory and Anti-Angiogenic Properties of Resveratrol in Ocular Diseases

Allan Lançon et al. Molecules. .
Free PMC article


Resveratrol (3,4',5 trihydroxy-trans-stilbene) is one of the best known phytophenols with pleiotropic properties. It is a phytoalexin produced by vine and it leads to the stimulation of natural plant defenses but also exhibits many beneficial effects in animals and humans by acting on a wide range of organs and tissues. These include the prevention of cardiovascular diseases, anti-cancer potential, neuroprotective effects, homeostasia maintenance, aging delay and a decrease in inflammation. Age-related macular degeneration (AMD) is one of the main causes of deterioration of vision in adults in developed countries This review deals with resveratrol and ophthalmology by focusing on the antioxidant, anti-inflammatory, and anti-angiogenic effects of this molecule. The literature reports that resveratrol is able to act on various cell types of the eye by increasing the level of natural antioxidant enzymatic and molecular defenses. Resveratrol anti-inflammatory effects are due to its capacity to limit the expression of pro-inflammatory factors, such as interleukins and prostaglandins, and also to decrease the chemo-attraction and recruitment of immune cells to the inflammatory site. In addition to this, resveratrol was shown to possess anti-VEGF effects and to inhibit the proliferation and migration of vascular endothelial cells. Resveratrol has the potential to be used in a range of human ocular diseases and conditions, based on animal models and in vitro experiments.

Keywords: eyes; inflammation; resveratrol.

Conflict of interest statement

The authors declare no conflict of interest.


Figure 1
Figure 1
Inhibitory effects of Resveratrol on COX1 and COX2 activities, two enzymes involved in the synthesis of pro-inflammatory leukotrienes. Resv, resveratrol; COX-1 and COX-2, cyclo-oxygenases 1 and 2 [27].
Figure 2
Figure 2
Interleukins and VEGF-A assays on resveratrol-treated retina ARPE-19 cell lines. Data are mean ± SD (n = 3); 1% of solvent DM SO was used as a vehicle in all treatments. Mann-Whitney Test * p ≤ 0.05.

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    1. Takaoka M.J. Of the phenolic substances of white hellebore (Veratrum grandiflorum Loes. fil.) J. Fac. Sci. Hokkaido Imp. Univ. 1940;3:1–16. doi: 10.1246/nikkashi1921.60.1261. - DOI
    1. Nonomura S., Kanagawa H., Makimoto A. Chemical Constituents of Polygonaceous Plants. I. Studies on the Components of Ko-J O-Kon. (Polygonum Cuspidatum Sieb. Et Zucc.) Yakugaku Zasshi. 1963;83:988–990. - PubMed
    1. Langcake P., Pryce R.J. The production of resveratrol by Vitis vinifera and other members of the Vitaceae as a response to infection or injury. Physiol. Plant Pathol. 1976;9:77–86. doi: 10.1016/0048-4059(76)90077-1. - DOI
    1. Delmas D., Jannin B., Latruffe N. Resveratrol: Preventing properties against vascular alterations and ageing. Mol. Nutr. Food Res. 2005;49:377–395. doi: 10.1002/mnfr.200400098. - DOI - PubMed
    1. Colin D., Gimazane A., Lizard G., Izard J.C., Solary E., Latruffe N., Delmas D. Effects of resveratrol analogs on cell cycle progression, cell cycle associated proteins and 5-fluoro-uracil sensitivity in human derived colon cancer cells. Int. J. Cancer. 2009;124:2780–2788. doi: 10.1002/ijc.24264. - DOI - PubMed

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