Safety of an Enhanced Recovery Pathway for Patients Undergoing Open Hepatic Resection

PLoS One. 2016 Mar 7;11(3):e0150782. doi: 10.1371/journal.pone.0150782. eCollection 2016.


Background: Enhanced recovery pathways (ERP) have not been widely implemented for hepatic surgery. The aim of this study was to evaluate the safety of an ERP for patients undergoing open hepatic resection.

Methods: A single-surgeon, retrospective observational cohort study was performed comparing the clinical outcomes of patients undergoing open hepatic resection treated before and after implementation of an ERP. Morbidity, mortality, and length of hospital stay (LOS) were compared between pre-ERP and ERP groups.

Results: 126 patients (pre-ERP n = 73, ERP n = 53) were identified for the study. Patient characteristics and operative details were similar between groups. Overall complication rate was similar between pre-ERP and ERP groups (37% vs. 28%, p = 0.343). Before and after pathway implementation, the median LOS was similar, 5 (IQR 4-7) vs. 5 (IQR 4-6) days, p = 0.708. After adjusting for age, type of liver resection, and ASA, the ERP group had no increased risk of major complication (OR 0.38, 95% CI 0.14-1.02, p = 0.055) or LOS greater than 5 days (OR 1.21, 95% CI 0.56-2.62, p = 0.627).

Conclusions: Routine use of a multimodal ERP is safe and is not associated with increased postoperative morbidity after open hepatic resection.

MeSH terms

  • Aged
  • Cohort Studies
  • Female
  • Hepatectomy / adverse effects
  • Hepatectomy / methods*
  • Humans
  • Length of Stay
  • Male
  • Middle Aged
  • Patient Care / methods*
  • Retrospective Studies
  • Safety