Mitochondrial RNA granules: Compartmentalizing mitochondrial gene expression

J Cell Biol. 2016 Mar 14;212(6):611-4. doi: 10.1083/jcb.201507125. Epub 2016 Mar 7.


In mitochondria, DNA replication, gene expression, and RNA degradation machineries coexist within a common nondelimited space, raising the question of how functional compartmentalization of gene expression is achieved. Here, we discuss the recently characterized "mitochondrial RNA granules," mitochondrial subdomains with an emerging role in the regulation of gene expression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA Replication / genetics
  • Gene Expression / genetics*
  • Genes, Mitochondrial / genetics
  • Humans
  • Mitochondria / genetics*
  • RNA / genetics*
  • RNA, Mitochondrial


  • RNA, Mitochondrial
  • RNA