The emerging role of GATA transcription factors in development and disease

Expert Rev Mol Med. 2016 Mar 8;18:e3. doi: 10.1017/erm.2016.2.

Abstract

The GATA family of transcription factors consists of six proteins (GATA1-6) which are involved in a variety of physiological and pathological processes. GATA1/2/3 are required for differentiation of mesoderm and ectoderm-derived tissues, including the haematopoietic and central nervous system. GATA4/5/6 are implicated in development and differentiation of endoderm- and mesoderm-derived tissues such as induction of differentiation of embryonic stem cells, cardiovascular embryogenesis and guidance of epithelial cell differentiation in the adult.

Publication types

  • Review

MeSH terms

  • Animals
  • Cardiovascular System / growth & development
  • Cardiovascular System / metabolism
  • Cell Differentiation
  • Central Nervous System / growth & development
  • Central Nervous System / metabolism
  • Embryonic Stem Cells / cytology
  • Embryonic Stem Cells / metabolism
  • Endoderm / cytology
  • Endoderm / growth & development
  • Endoderm / metabolism*
  • Epithelial Cells / cytology
  • Epithelial Cells / metabolism
  • GATA Transcription Factors / genetics*
  • GATA Transcription Factors / metabolism
  • Gene Expression Regulation, Developmental*
  • Hematopoietic System / growth & development
  • Hematopoietic System / metabolism
  • Humans
  • Mesoderm / cytology
  • Mesoderm / growth & development
  • Mesoderm / metabolism*
  • Mutation
  • Neoplasms / genetics*
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Porphyria, Erythropoietic / genetics
  • Porphyria, Erythropoietic / metabolism
  • Porphyria, Erythropoietic / pathology
  • Signal Transduction

Substances

  • GATA Transcription Factors