Nutraceuticals in Migraine: A Summary of Existing Guidelines for Use

Headache. 2016 Apr;56(4):808-16. doi: 10.1111/head.12789. Epub 2016 Mar 7.


Background: The use of nutraceuticals or food/herbal products for health benefits is expanding in adults with migraine as they seek relief from pain in an effective and tolerable manner not always afforded by current conventional pharmacologic therapies. Guidelines from the American Academy of Neurology/American Headache Society, Canadian Headache Society, and European Federation of Neurological Societies have discussed nutraceuticals in varying degrees of detail with at times conflicting recommendations.

Conclusion: This review serves to provide a summary of existing guidelines for the use of certain nutraceuticals including riboflavin, coenzyme Q10, magnesium, butterbur, feverfew, and omega-3 polyunsaturated fatty acids. The review will also discuss the regulation of nutraceuticals in North America and the current controversy regarding butterbur and its safety.

Keywords: herbal; migraine; nutraceutical; prophylaxis; supplement.

Publication types

  • Review

MeSH terms

  • Dietary Supplements* / adverse effects
  • Humans
  • Migraine Disorders / drug therapy
  • Practice Guidelines as Topic*