Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2016 Jul;80(1):92-100.
doi: 10.1038/pr.2016.39. Epub 2016 Mar 8.

Intratracheal Atomized Surfactant Provides Similar Outcomes as Bolus Surfactant in Preterm Lambs With Respiratory Distress Syndrome

Affiliations

Intratracheal Atomized Surfactant Provides Similar Outcomes as Bolus Surfactant in Preterm Lambs With Respiratory Distress Syndrome

Ilaria Milesi et al. Pediatr Res. .

Abstract

Background: Aerosolization of exogenous surfactant remains a challenge. This study is aimed to evaluate the efficacy of atomized poractant alfa (Curosurf) administered with a novel atomizer in preterm lambs with respiratory distress syndrome.

Methods: Twenty anaesthetized lambs, 127 ± 1 d gestational age, (mean ± SD) were instrumented before birth and randomized to receive either (i) positive pressure ventilation without surfactant (Control group), (ii) 200 mg/kg of bolus instilled surfactant (Bolus group) at 10 min of life or (iii) 200 mg/kg of atomized surfactant (Atomizer group) over 60 min from 10 min of life. All lambs were ventilated for 180 min with a standardized protocol. Lung mechanics, regional lung compliance (electrical impedance tomography), and carotid blood flow (CBF) were measured with arterial blood gas analysis.

Results: Dynamic compliance and oxygenation responses were similar in the Bolus and Atomizer groups, and both better than Control by 180 min (all P < 0.05; two-way ANOVA). Both surfactant groups demonstrated more homogeneous regional lung compliance throughout the study period. There were no differences in CBFConclusion:In a preterm lamb model, atomized surfactant resulted in similar gas exchange and mechanics as bolus administration. This study suggests evaluation of supraglottic atomization with this system when noninvasive support is warranted.

Similar articles

See all similar articles

Cited by 7 articles

See all "Cited by" articles

References

    1. J Appl Physiol (1985). 1991 Feb;70(2):869-76 - PubMed
    1. J Appl Physiol (1985). 2015 Apr 1;118(7):890-7 - PubMed
    1. Pediatr Res. 1996 Jun;39(6):953-7 - PubMed
    1. BMC Pediatr. 2014 Feb 15;14:43 - PubMed
    1. Respir Med. 2009 Oct;103(10):1400-5 - PubMed

Publication types

MeSH terms

LinkOut - more resources

Feedback