Tracking HSC Origin: From Bench to Placenta

Dev Cell. 2016 Mar 7;36(5):479-80. doi: 10.1016/j.devcel.2016.02.022.


Reporting in Developmental Cell, Pereira et al. (2016) use in vitro lineage reprogramming insights to inform understanding of hematopoietic stem cell (HSC) development in vivo. They find Prom1(+)Sca1(+)CD34(+)CD45(-) hemogenic precursors, akin to fibroblast-derived hemato-vascular precursors, in mouse placenta and embryo. The cells mature into transplantable HSCs in culture.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Differentiation / physiology*
  • Cell Lineage / physiology*
  • Cellular Reprogramming*
  • Female
  • Hematopoiesis / genetics*
  • Hematopoietic Stem Cells / cytology*
  • Mouse Embryonic Stem Cells / cytology*
  • Pregnancy