Sticking Around: Short-Range Activity of Wnt Ligands

Dev Cell. 2016 Mar 7;36(5):485-6. doi: 10.1016/j.devcel.2016.02.018.


Wnt ligands are secreted lipid-modified proteins that are essential for development and homeostasis. Published recently in Nature, Farin et al. (2016) report that Wnt3 acts at a short distance during growth of mouse intestinal organoids, suggesting that Wnt proteins remain membrane-bound to activate signaling at a short range from their source.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Membrane / metabolism*
  • Female
  • Intestinal Mucosa / cytology*
  • Male
  • Stem Cell Niche*
  • Stem Cells / cytology*
  • Stem Cells / metabolism*
  • Wnt Signaling Pathway*
  • Wnt3 Protein / metabolism*


  • Wnt3 Protein