Spermatogonial cells: mouse, monkey and man comparison

Carla Boitani; Sara Di Persio; Valentina Esposito; Elena Vicini

doi:10.1016/j.semcdb.2016.03.002

Spermatogonial cells: mouse, monkey and man comparison

Semin Cell Dev Biol. 2016 Nov:59:79-88. doi: 10.1016/j.semcdb.2016.03.002. Epub 2016 Mar 5.

Authors

Carla Boitani¹, Sara Di Persio², Valentina Esposito³, Elena Vicini⁴

Affiliations

¹ Fondazione Pasteur Cenci Bolognetti and Department of Anatomical, Histological, Forensic and Orthopedic Sciences-Section of Histology and Medical Embryology, Sapienza University of Rome, Via Antonio Scarpa, 14, 00161 Rome, Italy. Electronic address: carla.boitani@uniroma1.it.
² Fondazione Pasteur Cenci Bolognetti and Department of Anatomical, Histological, Forensic and Orthopedic Sciences-Section of Histology and Medical Embryology, Sapienza University of Rome, Via Antonio Scarpa, 14, 00161 Rome, Italy. Electronic address: sara.dipersio@uniroma1.it.
³ Fondazione Pasteur Cenci Bolognetti and Department of Anatomical, Histological, Forensic and Orthopedic Sciences-Section of Histology and Medical Embryology, Sapienza University of Rome, Via Antonio Scarpa, 14, 00161 Rome, Italy. Electronic address: valentina.esposito@uniroma1.it.
⁴ Fondazione Pasteur Cenci Bolognetti and Department of Anatomical, Histological, Forensic and Orthopedic Sciences-Section of Histology and Medical Embryology, Sapienza University of Rome, Via Antonio Scarpa, 14, 00161 Rome, Italy. Electronic address: elena.vicini@uniroma1.it.

PMID: 26957475
DOI: 10.1016/j.semcdb.2016.03.002

Abstract

In all mammals, spermatogonia are defined as constituting the mitotic compartment of spermatogenesis including stem, undifferentiated and differentiating cell types, possessing distinct morphological and molecular characteristics. Even though the real nature of the spermatogonial stem cell and its regulation is still debated the general consensus holds that in steady-state spermatogenesis the stem cell compartment needs to balance differentiation versus self-renewal. This review highlights current understanding of spermatogonial biology, the kinetics of amplification and the signals directing spermatogonial differentiation in mammals. The focus will be on relevant similarities and differences between rodents and non human and human primates.

Keywords: Human; Mouse; Non-human primates; Spermatogonia; Spermatogonial stem cell niche; Spermatogonial stem cells.

Publication types

Comparative Study
Review
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Differentiation
Haplorhini
Humans
Kinetics
Male
Mice
Models, Biological
Phenotype
Spermatogonia / cytology*
Stem Cell Niche