Uveal melanoma radiation. 125I brachytherapy versus helium ion irradiation

Ophthalmology. 1989 Dec;96(12):1708-15.


The optimum radiation therapy for uveal melanoma is uncertain. Both helium ion irradiation and 125I brachytherapy have been used to treat this neoplasm. This investigation analyzed the control and complication rates of uveal melanomas treated with helium ions of 125I plaques. In both a retrospective and a prospective dynamically balanced study, the control rates appeared to be similar. There were more posterior segment complications after 125I plaques and more anterior segment complications, including neovascular glaucoma, after helium ion irradiation. The follow-up period is too short to draw definitive conclusions on the radiation complications. Overall, approximately 89% of eyes were retained and less than 4% of treated eyes were removed because of failure to control the tumor.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brachytherapy* / adverse effects
  • Follow-Up Studies
  • Helium / adverse effects
  • Helium / therapeutic use*
  • Humans
  • Iodine Radioisotopes / adverse effects
  • Iodine Radioisotopes / therapeutic use*
  • Melanoma / mortality
  • Melanoma / radiotherapy*
  • Melanoma / secondary
  • Middle Aged
  • Prospective Studies
  • Randomized Controlled Trials as Topic
  • Retrospective Studies
  • Survival Analysis
  • Uveal Neoplasms / mortality
  • Uveal Neoplasms / radiotherapy*


  • Iodine Radioisotopes
  • Helium