Intravascular Myopericytoma of the Plantar Region: Case Report and Discussion of the Probable Origin From a Cutaneous Vascular Malformation

Am J Dermatopathol. 2016 Jul;38(7):546-8. doi: 10.1097/DAD.0000000000000522.


Myopericytoma is a perivascular myoid neoplasm of skin and soft tissues characterized by numerous thin-walled blood vessels surrounded concentrically by round to spindle myoid tumor cells, which shows α-smooth muscle actin and h-caldesmon coexpression and commonly negativity for desmin. These tumors arise predominantly in extremities of adult patients with benign clinical course. Based on the architectural pattern, there are various histologic variants as classical-solid myopericytoma, hemangiopericytoma-like myopericytoma, angioleiomyoma-like myopericytoma, myofibroma-like myopericytoma, hipocelular fibroma-like myopericytoma, intravascular myopericytoma, cellular immature myopericytoma, and malignant myopericytoma. The authors report a case that fully satisfies the morphological and immunohistochemical criteria for intravascular myopericytoma, which plantar location is not previously described in the literature. In addition, the authors discuss about its possible development from a preexistent cutaneous vascular malformation.

Publication types

  • Case Reports

MeSH terms

  • Biomarkers, Tumor / analysis
  • Biopsy
  • Female
  • Foot
  • Hemangiopericytoma / chemistry
  • Hemangiopericytoma / etiology*
  • Hemangiopericytoma / pathology
  • Hemangiopericytoma / surgery
  • Humans
  • Immunohistochemistry
  • Middle Aged
  • Skin / blood supply*
  • Vascular Malformations / complications*
  • Vascular Malformations / diagnosis
  • Vascular Neoplasms / chemistry
  • Vascular Neoplasms / etiology*
  • Vascular Neoplasms / pathology
  • Vascular Neoplasms / surgery


  • Biomarkers, Tumor