Fecal Microbiota Transplantation Inhibits Multidrug-Resistant Gut Pathogens: Preliminary Report Performed in an Immunocompromised Host

Arch Immunol Ther Exp (Warsz). 2016 Jun;64(3):255-8. doi: 10.1007/s00005-016-0387-9. Epub 2016 Mar 9.


Colonization of the gastrointestinal tract with multidrug-resistant (MDR) bacteria is a consequence of gut dysbiosis. We describe the successful utilization of fecal microbiota transplantation to inhibit Klebsiella pneumoniae MBL(+) and Escherichia coli ESBL(+) gut colonization in the immunocompromised host as a novel tool in the battle against MDR microorganisms. ClinicalTrials.gov identifier NCT02461199.

Keywords: Antibiotic-resistant bacteria; Fecal microbiota transplantation; Gut colonization.

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Anti-Bacterial Agents / therapeutic use*
  • Antineoplastic Agents / adverse effects
  • Drug Resistance, Bacterial
  • Drug Resistance, Multiple
  • Dysbiosis / therapy
  • Escherichia coli
  • Fecal Microbiota Transplantation / methods*
  • Female
  • Humans
  • Immunocompromised Host*
  • Intestinal Mucosa / microbiology*
  • Klebsiella pneumoniae
  • Male
  • Microbiota
  • Middle Aged
  • Multiple Myeloma / complications
  • Multiple Myeloma / drug therapy
  • Phenotype
  • Young Adult


  • Anti-Bacterial Agents
  • Antineoplastic Agents

Associated data

  • ClinicalTrials.gov/NCT02461199