Actin' on HIV: How Dendritic Cells Spread Infection

Daniel A Donahue; Olivier Schwartz

doi:10.1016/j.chom.2016.02.016

Actin' on HIV: How Dendritic Cells Spread Infection

Cell Host Microbe. 2016 Mar 9;19(3):267-9. doi: 10.1016/j.chom.2016.02.016.

Authors

Daniel A Donahue¹, Olivier Schwartz²

Affiliations

¹ Institut Pasteur, Department of Virology, Virus & Immunity Unit, Paris 75015, France; CNRS URA 3015, Paris 75015, France. Electronic address: ddonahue@pasteur.fr.
² Institut Pasteur, Department of Virology, Virus & Immunity Unit, Paris 75015, France; CNRS URA 3015, Paris 75015, France; Vaccine Research Institute, Creteil 94010, France. Electronic address: schwartz@pasteur.fr.

PMID: 26962935
DOI: 10.1016/j.chom.2016.02.016

Abstract

Dendritic cells (DCs) capture HIV particles and transmit them to CD4 T cells. In a recent article published in Cell, Ménager and Littman (2016) perform an shRNA screen in DCs and find that actin nucleation and stabilization regulate HIV uptake and maintain the virus on membrane protrusions for efficient transfer.

Publication types

Comment

MeSH terms

Actins / metabolism*
Dendritic Cells / immunology*
HIV Infections / immunology*
HIV-1 / physiology*
Humans
T-Lymphocytes / immunology*

Substances

Actins