[(11)C]Ascorbic and [(11)C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography

Chem Commun (Camb). 2016 Apr 7;52(27):4888-90. doi: 10.1039/c6cc00895j. Epub 2016 Mar 10.

Abstract

Here we report the radiosynthesis of an endogenous redox pair, [(11)C]ascorbic acid ([(11)C]VitC) and [(11)C]dehydroascorbic acid ([(11)C]DHA), the reduced and oxidized forms of vitamin C, and their application to ROS sensing. These results provide the basis for in vivo detection of ROS using positron emission tomography (PET).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Ascorbic Acid / chemistry*
  • Carbon Radioisotopes / chemistry*
  • Oxidation-Reduction
  • Positron-Emission Tomography*
  • Reactive Oxygen Species / analysis*

Substances

  • Carbon Radioisotopes
  • Reactive Oxygen Species
  • Ascorbic Acid