Subcutaneous Immunoglobulin in Refractory Juvenile Dermatomyositis

Pediatrics. 2016 Apr;137(4):e20153537. doi: 10.1542/peds.2015-3537. Epub 2016 Mar 10.

Abstract

Juvenile dermatomyositis (JDM) is the most common form of juvenile idiopathic inflammatory myopathy. We report a child with steroid-dependent JDM refractory to hydroxychloroquine and subcutaneous methotrexate who experienced systemic reactions to intravenous immunoglobulin and was successfully treated with subcutaneous immunoglobulin. This form of therapy has been shown to be safe, has a very low rate of adverse effects, does not require hospital admission, reduces the number of missed school days, and decreases the costs associated with treatment.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Dermatomyositis / drug therapy*
  • Female
  • Glucocorticoids / therapeutic use
  • Humans
  • Immunoglobulins / administration & dosage*
  • Immunoglobulins, Intravenous / therapeutic use
  • Injections, Subcutaneous
  • Prednisone / therapeutic use

Substances

  • Glucocorticoids
  • Immunoglobulins
  • Immunoglobulins, Intravenous
  • Prednisone