Hardwiring Stem Cell Communication through Tissue Structure

Cell. 2016 Mar 10;164(6):1212-1225. doi: 10.1016/j.cell.2016.02.041.


Adult stem cells across diverse organs self-renew and differentiate to maintain tissue homeostasis. How stem cells receive input to preserve tissue structure and function largely relies on their communication with surrounding cellular and non-cellular elements. As such, how tissues are organized and patterned not only reflects organ function, but also inherently hardwires networks of communication between stem cells and their environment to direct tissue homeostasis and injury repair. This review highlights how different methods of stem cell communication reflect the unique organization and function of diverse tissues.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adult Stem Cells / cytology
  • Animals
  • Cell Communication*
  • Homeostasis
  • Humans
  • Regeneration
  • Stem Cells / cytology