Signaling in Host-Associated Microbial Communities

Cell. 2016 Mar 10;164(6):1288-1300. doi: 10.1016/j.cell.2016.02.037.


Human-associated microbiota form and stabilize communities based on interspecies interactions. We review how these microbe-microbe and microbe-host interactions are communicated to shape communities over a human's lifespan, including periods of health and disease. Modeling and dissecting signaling in host-associated communities is crucial to understand their function and will open the door to therapies that prevent or correct microbial community dysfunction to promote health and treat disease.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bacteria / classification
  • Bacteria / metabolism
  • Humans
  • Microbial Interactions
  • Microbiota*
  • Signal Transduction*