Effect of dietary supplementation with inulin and/or benzoic acid on the incidence and severity of post-weaning diarrhoea in weaner pigs after experimental challenge with enterotoxigenic Escherichia coli

Arch Anim Nutr. 2009;63(4):267-80. doi: 10.1080/17450390903020414.

Abstract

The purpose of this study was to evaluate the effects of feeding pigs with inulin and/or benzoic acid on post-weaning diarrhoea (PWD), indices of fermentation in the gastrointestinal tract, and production in pigs experimentally infected with an enterotoxigenic strain of Escherichia coli (ETEC). Forty-eight entire male pigs (Large White×Landrace) aged 21 ± 3 days of age and weighing 4.97 ± 0.08 kg (mean ± SE) were used in a 2×2 factorial experiment, with the respective factors being inulin (0 versus 8%) and benzoic acid (0 vs. 0.5%). Feeding inulin-supplemented diets improved (p = 0.022) the faecal consistency (FC) and reduced (p = 0.001) the incidence of PWD; however, the use of benzoic acid had no effects on PWD or faecal ETEC shedding. Wet faeces (a higher FC score) were associated with increased faecal ETEC shedding (R(2) = 0.394, p = 0.001). Inulin reduced the total concentrations of short chain fatty acids (p = 0.029) in the proximal colon. The total concentration of lactic acid was increased by inulin in the caecum (p = 0.007) and proximal colon (p = 0.002). Feeding inulin or benzoic acid had no effects on production after weaning.

Keywords: benzoic acid; diarrhoea; inulin; pigs; post-weaning interval.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animal Feed / analysis
  • Animal Nutritional Physiological Phenomena
  • Animals
  • Benzoic Acid* / administration & dosage
  • Diarrhea / epidemiology
  • Diarrhea / microbiology
  • Diarrhea / therapy
  • Diarrhea / veterinary*
  • Diet / veterinary
  • Dietary Supplements* / analysis
  • Enterotoxigenic Escherichia coli / physiology*
  • Escherichia coli Infections / drug therapy
  • Escherichia coli Infections / epidemiology
  • Escherichia coli Infections / microbiology
  • Escherichia coli Infections / veterinary*
  • Fermentation
  • Gastrointestinal Tract / metabolism
  • Gastrointestinal Tract / pathology
  • Incidence
  • Inulin* / administration & dosage
  • Male
  • Swine / physiology
  • Swine Diseases / epidemiology
  • Swine Diseases / microbiology
  • Swine Diseases / therapy*
  • Weaning

Substances

  • Benzoic Acid
  • Inulin