Whole Genome Linkage Analysis Followed by Whole Exome Sequencing Identifies Nicastrin (NCSTN) as a Causative Gene in a Multiplex Family with γ-Secretase Spectrum of Autoinflammatory Skin Phenotypes

Affiliations

• ¹ Kariminejad-Najmabadi Pathology and Genetics Center, Tehran, Iran.
• ² Clinical Research Unit, Afzalipoor Hospital, Kerman University of Medical Sciences, Kerman, Iran.
• ³ Kariminejad-Najmabadi Pathology and Genetics Center, Tehran, Iran; Genetics Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
• ⁴ Dalla Lana School of Public Health, University of Toronto, Toronto, Canada; Women's College Research Institute, University of Toronto, Toronto, Canada.
• ⁵ Leishmaniasis Research Center, Kerman University of Medical Sciences, Kerman, Iran.
• ⁶ Biotechnology Research Center, Department of Molecular Medicine, Pasteur Institute of Iran, Tehran, Iran; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
• ⁷ Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.
• ⁸ Kariminejad-Najmabadi Pathology and Genetics Center, Tehran, Iran. Electronic address: arianakariminejad@yahoo.com.