Brief Client-Centered Motivational and Behavioral Intervention to Promote HPV Vaccination in a Hard-to-Reach Population: A Pilot Randomized Controlled Trial

Clin Pediatr (Phila). 2016 Aug;55(9):851-9. doi: 10.1177/0009922815616244. Epub 2016 Mar 10.


Objective To evaluate the impact of a client-centered behavioral intervention (Brief Negotiated Interviewing) on mothers' human papillomavirus (HPV) vaccine knowledge and vaccination initiation for their adolescent daughters. Methods We randomized mothers to intervention (n = 100) and control (n = 100) groups, and followed them over 12 months. Electronic medical records were reviewed to determine vaccination status. The primary outcome was receipt of the first vaccine. The secondary outcome was HPV vaccine knowledge among mothers. Results Brief Negotiated Interviewing intervention mothers demonstrated increased knowledge about HPV (pre/post mean score of 5 to 10 out of a possible 11; P < .001) and significantly higher mean knowledge scores (10 vs 6, P < .001) than control mothers. However, initiation and completion rates of the vaccine were not significantly different between groups. Conclusions Increasing HPV vaccine knowledge did not translate into increased vaccine uptake or completion of vaccination series. Future intervention must explore vaccine reminders to increase HPV vaccination rates.

Keywords: Brief Negotiated Interview/motivational intervention; HPV vaccination; Haitian mothers; adolescent girls; hard-to-reach populations; minority and low income; pilot trial.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Adult
  • Behavior Therapy / methods*
  • Black or African American / statistics & numerical data
  • Female
  • Haiti / ethnology
  • Health Knowledge, Attitudes, Practice*
  • Health Promotion / methods*
  • Humans
  • Mothers
  • Motivational Interviewing / methods*
  • Nuclear Family
  • Papillomavirus Infections / prevention & control*
  • Papillomavirus Vaccines / therapeutic use*
  • Pilot Projects


  • Papillomavirus Vaccines