Microtubule plus-end tracking proteins in neuronal development

Cell Mol Life Sci. 2016 May;73(10):2053-77. doi: 10.1007/s00018-016-2168-3. Epub 2016 Mar 11.


Regulation of the microtubule cytoskeleton is of pivotal importance for neuronal development and function. One such regulatory mechanism centers on microtubule plus-end tracking proteins (+TIPs): structurally and functionally diverse regulatory factors, which can form complex macromolecular assemblies at the growing microtubule plus-ends. +TIPs modulate important properties of microtubules including their dynamics and their ability to control cell polarity, membrane transport and signaling. Several neurodevelopmental and neurodegenerative diseases are associated with mutations in +TIPs or with misregulation of these proteins. In this review, we focus on the role and regulation of +TIPs in neuronal development and associated disorders.

Keywords: CLASP; CLIP; Cytoskeleton; Development; EB; Microtubule; Neuron; Plus-end tracking proteins; Polarity.

Publication types

  • Review

MeSH terms

  • Alzheimer Disease / pathology
  • Animals
  • Axons / metabolism
  • Brain Diseases / pathology
  • Cell Membrane / metabolism
  • Cell Polarity
  • Cytoskeleton / metabolism
  • Dendrites / metabolism
  • Humans
  • Microtubule-Associated Proteins / metabolism
  • Microtubules / metabolism
  • Microtubules / physiology*
  • Mutation
  • Neurites / metabolism
  • Neurogenesis / physiology
  • Neurons / metabolism
  • Neurons / pathology
  • Neurons / physiology*
  • Protein Binding
  • Signal Transduction
  • Synapses / metabolism


  • Microtubule-Associated Proteins