Applied Developmental Biology: Making Human Pancreatic Beta Cells for Diabetics

Curr Top Dev Biol. 2016;117:65-73. doi: 10.1016/bs.ctdb.2015.11.013. Epub 2016 Jan 20.

Abstract

Understanding the genes and signaling pathways that determine the differentiation and fate of a cell is a central goal of developmental biology. Using that information to gain mastery over the fates of cells presents new approaches to cell transplantation and drug discovery for human diseases including diabetes.

Keywords: Beta cell; Diabetes; Differentiation; Pancreas; Stem cell.

Publication types

  • Review

MeSH terms

  • Animals
  • Developmental Biology*
  • Diabetes Mellitus / therapy*
  • Humans
  • Insulin-Secreting Cells / cytology*
  • Insulin-Secreting Cells / transplantation*
  • Signal Transduction