Mixed vitiligo of Blaschko lines: a newly discovered presentation of vitiligo responsive to combination treatment

Dermatol Ther. 2016 Jul;29(4):240-3. doi: 10.1111/dth.12345. Epub 2016 Mar 11.


Vitiligo, depigmenting disorder of the skin and mucous membranes, affects up to 1% of the population worldwide. It is classified into four major types: segmental, non-segmental, mixed, and unclassified type. Non-segmental vitiligo refers to non-dermatomal distribution of lesions, while dermatomal distribution of lesions is present in patients with segmental vitiligo. Segmental vitiligo can also follow Blaschko lines - pathways of epidermal cell migration and proliferation during the development of the fetus. Here, we present patient with segmental and non-segmental vitiligo following Blaschko lines with excellent therapeutic response to combined therapy. Prior to our report, a case of segmental and non-segmental vitiligo followed by Blaschko lines was never described, therefore we suggest the term "mixed vitiligo of Blaschko lines" to describe this entity. This is also a rare case in which 90% repigmentation was achieved in patient with segmental and nonsegmental vitiligo following Blaschko lines in only 2 months of combined therapy.

Keywords: Blaschko lines; mixed vitiligo; vitiligo.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antioxidants / therapeutic use
  • Clobetasol / therapeutic use
  • Combined Modality Therapy
  • Female
  • Humans
  • Phototherapy
  • Vitiligo / pathology
  • Vitiligo / therapy*


  • Antioxidants
  • Clobetasol