Succinate, an intermediate in metabolism, signal transduction, ROS, hypoxia, and tumorigenesis

Biochim Biophys Acta. 2016 Aug;1857(8):1086-1101. doi: 10.1016/j.bbabio.2016.03.012. Epub 2016 Mar 10.

Abstract

Succinate is an important metabolite at the cross-road of several metabolic pathways, also involved in the formation and elimination of reactive oxygen species. However, it is becoming increasingly apparent that its realm extends to epigenetics, tumorigenesis, signal transduction, endo- and paracrine modulation and inflammation. Here we review the pathways encompassing succinate as a metabolite or a signal and how these may interact in normal and pathological conditions.(1).

Keywords: Cancer; HIF1-alpha; Substrate-level phosphorylation; Succinate dehydrogenase; Succinate receptor.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Carcinogenesis / genetics
  • Carcinogenesis / metabolism*
  • Carcinogenesis / pathology
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Hypoxia / genetics
  • Hypoxia / metabolism*
  • Hypoxia / pathology
  • Hypoxia-Inducible Factor 1, alpha Subunit / genetics
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
  • Metabolic Networks and Pathways / genetics
  • Mutation
  • Neoplasms / genetics
  • Neoplasms / metabolism*
  • Neoplasms / pathology
  • Paracrine Communication / genetics
  • Protein Subunits / genetics
  • Protein Subunits / metabolism
  • Reactive Oxygen Species / metabolism
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism
  • Signal Transduction
  • Succinate Dehydrogenase / genetics
  • Succinate Dehydrogenase / metabolism*
  • Succinic Acid / metabolism

Substances

  • HIF1A protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • Protein Subunits
  • Reactive Oxygen Species
  • Receptors, G-Protein-Coupled
  • Succinic Acid
  • Succinate Dehydrogenase