A rapid-response fluorescent probe for the sensitive and selective detection of human albumin in plasma and cell culture supernatants

Chem Commun (Camb). 2016 May 4;52(36):6064-7. doi: 10.1039/c6cc00119j. Epub 2016 Mar 14.

Abstract

A rapid-response fluorescent probe ACDM was developed for the selective and sensitive detection of human albumin (HA) via binding onto a non-drug binding site. ACDM was successfully used to detect trace HA in various biological samples including diluted plasma and cell culture supernatants.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Binding Sites
  • Chemistry Techniques, Analytical / methods*
  • Chromatography, High Pressure Liquid
  • Fluorescent Dyes / chemistry*
  • Furans / chemistry
  • Hep G2 Cells
  • Humans
  • Molecular Dynamics Simulation
  • Protein Structure, Tertiary
  • Serum Albumin / analysis*
  • Serum Albumin / chemistry
  • Tandem Mass Spectrometry

Substances

  • Fluorescent Dyes
  • Furans
  • Serum Albumin
  • furan