Relationship between CD14-159C/T gene polymorphism and acute brucellosis risk

Mehdi Moghadampour; Ebrahim Eskandari-Nasab; Fatemeh Shabani

doi:10.1016/j.apjtm.2016.01.036

Relationship between CD14-159C/T gene polymorphism and acute brucellosis risk

Asian Pac J Trop Med. 2016 Mar;9(3):247-51. doi: 10.1016/j.apjtm.2016.01.036. Epub 2016 Jan 12.

Authors

Mehdi Moghadampour¹, Ebrahim Eskandari-Nasab², Fatemeh Shabani³

Affiliations

¹ Department of Microbiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran; Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
² Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran; Genetic of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran. Electronic address: eenasab@yahoo.com.
³ School of Medicine, Jiroft University of Medical Sciences, Jiroft, Kerman, Iran.

Abstract

Objective: To investigate the association between the cluster of differentiation 14 (CD14)-159C/T (rs2569190) gene polymorphism and susceptibility to acute brucellosis in an Iranian population.

Methods: The study included 153 Iranian patients with active brucellosis and 128 healthy individuals as the control group. Genotyping of the CD14 variant was performed using an amplification refractory mutation system-polymerase chain reaction method.

Results: The prevalence of CD14-159 TT and CT genotypes were associated with increased risk of brucellosis [odds ratio (OR) = 1.993, 95% confidence interval (95% CI) = 1.07-3.71, P = 0.03 for CT; OR = 3.869, 95% CI = 1.91-7.84, P = 0.01 for TT genotype. Additionally, the minor allele (T) was significantly more frequently present in brucellosis patients than in controls (61% vs. 45%, respectively), and was a risk factor for brucellosis (OR = 3.058, 95% CI = 1.507-6.315, P = 0.01).

Conclusions: The findings provided suggestive evidence of association of the CD14-159C/T gene polymorphism with susceptibility to acute brucellosis in the Iranian population.

Keywords: Acute brucellosis; Cluster of differentiation 14; Single nucleotide polymorphism.