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. 2016 May;48(5):497-9.
doi: 10.1038/ng.3527. Epub 2016 Mar 14.

Epigenetic Germline Inheritance of Diet-Induced Obesity and Insulin Resistance

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Epigenetic Germline Inheritance of Diet-Induced Obesity and Insulin Resistance

Peter Huypens et al. Nat Genet. .

Abstract

There is considerable controversy regarding epigenetic inheritance in mammalian gametes. Using in vitro fertilization to ensure exclusive inheritance via the gametes, we show that a parental high-fat diet renders offspring more susceptible to developing obesity and diabetes in a sex- and parent of origin-specific mode. The epigenetic inheritance of acquired metabolic disorders may contribute to the current obesity and diabetes pandemic.

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