Long Noncoding RNAs in Psychiatric Disorders

Psychiatr Genet. 2016 Jun;26(3):109-16. doi: 10.1097/YPG.0000000000000129.

Abstract

Long noncoding RNAs (lncRNAs) are nonprotein coding transcripts longer than 200 nucleotides. Many of these lncRNAs have regulatory functions and have recently emerged as major players in governing fundamental biological processes. Here, we review the definition, distribution, identification, databases, analysis, classification, and functions of lncRNAs. We also discuss the potential roles of lncRNAs in the etiological processes of psychiatric disorders and the implications for clinical diagnosis and treatment.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Humans
  • Mental Disorders / genetics*
  • RNA, Long Noncoding / genetics*

Substances

  • RNA, Long Noncoding