Mitochondria-specific conjugated polymer nanoparticles

Chem Commun (Camb). 2016 Apr 7;52(27):4910-3. doi: 10.1039/c6cc00810k. Epub 2016 Mar 14.


Biodegradable conjugated polymer nanoparticles (CPNs) were prepared for high mitochondrial targeting in live cancer cells. The degradable CPNs are nontoxic and specifically localized to the mitochondria of live tumor cells through macropinocytosis followed by intracellular degradation and trafficking.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Microscopy, Confocal
  • Mitochondria / metabolism*
  • Nanoparticles / chemistry*
  • Pinocytosis
  • Polymers / chemistry*


  • Polymers