Haloperidol reduction can be assayed in human red blood cells

Can J Physiol Pharmacol. 1989 Nov;67(11):1468-9. doi: 10.1139/y89-237.

Abstract

One metabolite of haloperidol present in plasma is "reduced haloperidol." This study demonstrates that human red blood cells are capable of converting haloperidol to reduced haloperidol in vitro. The reductase involved requires NADPH, as does haloperidol (ketone) reductase in human liver cytosol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alcohol Oxidoreductases / blood
  • Chromatography, High Pressure Liquid
  • Erythrocytes / enzymology
  • Erythrocytes / metabolism*
  • Haloperidol / blood*
  • Haloperidol / metabolism
  • Humans
  • Male
  • NADP / metabolism
  • Oxidation-Reduction

Substances

  • NADP
  • Alcohol Oxidoreductases
  • haloperidol reductase
  • Haloperidol