Carcinoembryonic antigen: function in metastasis by human colorectal carcinoma

Cancer Metastasis Rev. 1989 Dec;8(3):263-80. doi: 10.1007/BF00047341.


Carcinoembryonic antigen (CEA) is a glycoprotein that has been useful as a tumor marker to predict recurrence in gastrointestinal malignancies, but whose biological function has not been elucidated. With the recent evidence that CEA is a member of the immunoglobulin supergene family, CEA may be involved in intercellular recognition and binding. This review examines the role that CEA plays in the development of metastases by colorectal carcinoma.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Carcinoembryonic Antigen / physiology*
  • Colorectal Neoplasms / pathology
  • Humans
  • Neoplasm Metastasis


  • Carcinoembryonic Antigen